Question & Answer

Can PMS Occur In The Middle Of Your Period?

Question: Can PMS occur during the middle of your period? Currently I’m in the middle of menstruation, and I’ve had mood swings, urges to cry and migraine/cramps for the past three days. Is this PMS related as it’s not before my period it’s during?

Moxie: PMS, mood swings, cramps, migraines, crying spells, and all the other horrible things PMS and PMDD bring are caused by estrogen levels falling too low. You will feel this way anytime your estrogen gets low which is usually right before your period but if you generally have low estrogen levels, you will feel like crap most of the time except those few days of your menstrual cycle when your estrogen is highest. Young women will have bi-polar-like behavior when their estrogen is low in their luteal phase, and feel good when estrogen higher in the follicular phase.

A horrible period means your estrogen is too low. If you had the right amount of estrogen, you wouldn’t have PMS or any of the symptoms associated with it. Your ovaries are under producing estrogen and the best way to get healthy menstrual cycles that are incident-free is to get out and move your body. Physical activity increases blood flow to our ovaries which in turn stimulates estrogen production. A crappy diet and poor sleep hygiene act as endocrine disruptors causing low estrogen production. Take care of your body. You have more control over how you feel than you think.  PMS is more of a choice of how you life your life.  

Can A Woman Get Too Much Estrogen?


Do you have too much estrogen?  A follower on Facebook asked, Can A Woman Get Too Much Estrogen? I get this question from time to time because women have heard the term estrogen dominance and it can get confusing.

Yes, you can have too much estrogen but that’s not to be confused with estrogen dominance, as they are two different things. Estrogen dominance is an estrogen deficiency issue, and having too much estrogen because your doctor is mis-dosing your hormones that take your estrogen level beyond your “Hormone Sweet Spot”, which causes a series of negative side effects. Properly optimizing hormones is intelligently administered in a way that titrates the estrogen blood serum levels up over a period of time to a certain point of which we call the “Hormone Sweet Spot”. This range for most women who check their blood on Day 12-13 of their cycle is somewhere between 300-700. There is a specific technique most doctors do not know to get their patients to this point. Our research foundation, Panacea Sciences Foundation for HRT Research, Development & Education, has clinical training protocols to help physicians and midlevels properly prescribe HRT. We found that when women went outside this range, whether above it or below it, they had what we call negative indicators.   If HRT is correctly prescribed, women cannot imagine feeling any better than they do and have virtually no negative indicators, and their labs concur; this is what we call the “Hormone Sweet Spot”. There’s a clinical skill to get patients to their “Hormone Sweet Spot”.

Estrogen dominance is often misinformed administration of low dosed hormones. We find women who take a second or third generation HRT system will get an estrogen dominance affect because the hormones are not intelligently prescribed to detoxify estrogen out of the body in a timely fashion.   Estrogen is not supposed to be stored in the body. If taken correctly, proper hormone restoration is designed to receive the hormones, utilize the hormones, and detoxify the hormones in a timely fashion. If it’s not done right, women will store that estrogen in fat until the receptor response is triggered, which never happens because the hormones are dosed too low and in the wrong way so women get fatter and fatter, and suffer from all the other miserable side effects of estrogen dominance. Women can also get estrogen dominance because of their crappy high carb and sugar diet as well. Women go to doctors for hormones as if the doctor knows what they’re doing. What women do not realize is Hormone Medicine is a specialty and going to someone who has no education or clinical training will make a mess of things and make you fat. I wrote an article about this called Estrogen Dominance or Deficient? where I discuss the difference between the two.  The Panacea Protocol is the most advance HRT system in the world and doesn’t cause estrogen dominance.  Find a clinician certified in the Panacea Protocol if you want proper hormone restoration to get rid of any estrogen dominance and lose the fat you’ve been holding onto.

What Hormone Labs Do I Take?

 Screen Shot 2016-08-26 at 2.41.10 PMI get a lot of questions about which hormone labs should they be taking, or which hormone labs they should ask their doctor to order.  The following is a recent message I received about hormone labs and other good questions.  I appreciate you all that send in good questions because so many others want to know as well.  I will always remove your name to protect your privacy.

“Tell me about what to ask my lady doctor I need specifically to test for so I can get my hormones in working condition?”

Moxie: First find out what she recommends for treatment of your miserable symptoms and ask “why” questions. It’s important you know what’s going on with your body because nobody cares about how you really feel but you no matter how “nice” your doctor is, so that means you have to be the driver of your own bus.   Educate yourself then ask why she/he is recommending the treatment they do, ask where they got their hormone specialty training (they don’t teach hormone replacement therapy in med school), ask what success they’ve had with this HRT treatment, and whatever else you want to know. Make sure your practitioner isn’t afraid of estrogen and warns you against it, and doesn’t dose too low. Most doctors who try to balance hormones that have no education or training, or went to the A4M, will dose your hormones too low, and not the right way. If your doctor is of this mindset and you take the hormones, you will feel good for a little bit, but they will stop working because the dose they prescribed doesn’t trigger a receptor response therefore most patients will respond with an estrogen dominance effect.

I don’t know what your doctor will do with regards to labs but the initial lab panel for female and MTF patients who are considering the Panacea Protocol, we take these labs:

  • Estradiol
  • FSH
  • Progesterone
  • LH
  • TSH
  • Total testosterone
  • Free testosterone
  • % of free testosterone
  • Bioavailable testosterone
  • SHBG
  • IGF-1 (if indicated)

You should already have had a female physical and other general labs to make sure you’re a medical candidate for advanced hormone replacement therapy. Not all patients are the same and depending on what you’re coming to the table with regarding past medical issues and other factors, will determine the clinical efficacy of your HRT.

If your doctor doesn’t know what initial hormone lab panel to take, then end your appointment and go to someone who will tell you what needs to be done because they have the knowledge experience. It’s not easy finding a doctor who isn’t afraid of estrogen who properly knows how to prescribe it. This is the biggest challenge physicians face so it becomes a challenge to find a doctor who’s “figured” it out.

“Should I beware of getting the wrong direction from her, an internal medicine specialist.”

Moxie: Most certainly. Med school teaches doctors how to treat and manage endocrine dysfunction issues with prescriptions, surgeries, or treatments but are not taught how to fix it altogether by restoring falling hormones back to healthy levels. If you had a heart attack, would you see a Chiropractor for heart surgery? They do not teach hormone replacement therapy in medical school. There are only a few institutions that educate about 2nd generation hormone therapy but it’s an old school mentality, in addition to offering no clinical instruction. Doctors are taught to keep the hormones low for the shortest amount of time but no one will tell you what that is exactly. We are already working on a 5th generation that address the progesterone lethargy and the thyroid/estrogen relationship, so most doctors who have some outside training are still misinformed.

“I have many upcoming appointments with specialists for…”

Moxie: Based on all the medical challenges you expressed of which I omitted from this post for your privacy, you have some things to take care of before really considering high dose 4th, or 5th generation hormone restoration therapies, the ones that restore hormones to healthy levels the right way. With all the medical issues you’re about to address, it will create havoc on your endocrine system and stress tolerance. It’s typically not recommend to start a good hormone protocol while under great stress, good or bad because cortisol being the trump hormone takes over the system in a way that no matter what hormones you’re taking, your body will have a difficult time accessing, utilizing, and detoxifying them in an appropriate manner, so most patients will get no positive effects of the hormones. After things calm down medically is the best time to consider HRT therapies in some manner. You medical history, diet, lifestyle, toxic load, and gut function will play a role in the efficacy of your hormone replacement therapy.

You have a bit of a challenging medical road ahead of you but if you have true concerns about osteoporosis, when you’ve been recovered for about six months, I highly recommend seeing a doctor who understands that estrogen deficiency causes osteoporosis, and uses high dose estrogen therapies to reverse or reduce it depending on your circumstance.

“I need to straighten out my hormones as I know I have been imbalanced since very very young.”

Moxie: Most women have always been estrogen or hormonally deficient. Most women have dysfunctional ovaries that do not produce enough of our main sex hormone that tells us if we want to live or die, and how we mentally and physically feel. There are many reasons young girls do not produce adequate estrogen at puberty and suffer greatly from PMS, PMDD, irrational behavior, irregular and painful menstrual cycles, headaches, mood swings, and bipolar-like behavior. These young women are prescribe birth control pills and anti-depressants and told to live with it. The biggest problem with this approach to medicine is it never addresses the true issue of the symptoms. These symptoms only exist in girls whose estrogen is too low. Putting a young girl on birth control pills puts her in immediate chemical menopause. If you’re ever read the package insert of the birth control pill you will see all the side effects are what old women deal with when their estrogen stops producing. Most women spend most of their lives in chemical or medical induced menopause. The longer a woman goes without estrogen the worse she feels mentally and physically. Our brains and bodies are designed to deteriorate and decay when estrogen is low making us mentally crazy and physically deteriorating.

“Any advice would be greatly appreciated and I will forever be Indebted to you for coming into my life.”

Moxie: Remember, you’re the driver of your own bus so never replace your judgment for someone else’s, including mine. If you pay attention to your brain and body, you’ll be able to make good decisions as to how to take care of it. Gather good information and decide what makes sense to you.



I think I’m In Perimenopause

Perimenopause 95

I get messages and emails about hormones, perimenopause, menopause, and menstrual cycles from around the world that many women ask me at one time or another. I will post these questions anonymously to protect privacy.  

This question was from a woman in the United States, and my response follows…

“I think I am well into perimenopause but as of yet, I am not under a doctor’s care. How possible is it to conquer this thing naturally?? I like to avoid any and all medication if possible. I just turned 42 and my cycle started taking some serious changes about 5 (maybe more) years ago. My mother went through it early as well. She did have hormone therapy, but was taken off of it when her doctor’s found it linked with heart problems and she is already a concern for that as she has Mitrol Valve Prolapse. Upon stopping the hormone therapy, she never had another period after that, and was still under 50 years of age. Doctor’s said without it she would likely have naturally stopped having periods several years sooner. I want to avoid medications and also don’t want to prolong it the way the medication did for her.”

Moxie’s responses:

“I think I am well into perimenopause but as of yet I like to avoid any and all medication if possible.”

 Moxie: Menopause is completely preventable. No woman needs to suffer menopause or any of its symptoms if she receives preventative treatment before the onset of menopause. Dr. Robert Wilson wrote about this in 1966 in his book Feminine Forever, and we found this to be the case on our Hormone Medicine Clinic as well.

” I am not under a doctor’s care.”

 Moxie: You may be under a doctor’s care, but that means nothing unless your practitioner understands the significance of estrogen on the female brain and body, AND what to effectively do about it. Doctors are not taught how to keep a woman’s estrogen from going into decline. They are taught how to manage the symptoms of estrogen and hormone deficiencies with prescription drugs or invasive procedures like hysterectomies. Finding an experienced HRT specialist will help best.

“How possible is it to conquer this thing naturally?”

Moxie: It’s more difficult to get a woman’s estrogen back up as it is to prevent it from declining in the first place. Women can do this with the proper lifestyle and diet if addressed early enough. The longer a woman is estrogen deficient, the harder it is to restore those levels with the recommended diet and lifestyle changes. Even when a woman addresses lifestyle and diet early enough, there will be a time where she will need to extraneously supplement hormones. Where you are in your hormonal decline is determined by certain blood lab levels, of which most doctors do not know.

“I just turned 42 and my cycle started taking some serious changes about 5 (maybe more) years ago.”

Moxie: This is very normal, and more so when women give birth in their mid-thirties when the hormones are beginning to decline. Women who’ve children in their mid-thirties tend to have more postpartum depression and other issues that never go away which gradually get worse the lower estrogen gets. Most women are estrogen deficient most of their lives but it really hits them at your age.

My mother went through it early as well.”

Moxie: You are not going through this early and neither did your mother. This is the time this process really affects women’s bodies and brains to the point they can’t take it anymore. This is also not a genetic issue, it’s a human and animal species issue. In the male and female human, the brain and body respond to main-sex hormone levels. When those hormone levels are in a particular healthy range, the brain and body thrive and protected against mental and physical dysfunction. When main-sex hormones are in unhealthy ranges, the brain and body deteriorated and begin to decline and decay. The mental and physical decline you are experiencing is physiologically and physically normal.

She did have hormone therapy, but was taken off of it when her doctor’s found it linked with heart problems and she is already a concern for that as she has Mitrol Valve Prolapse.”

Moxie: I’ve never been able to find those studies these doctors use to justify taking women off hormones or preventing them from adequate levels of estrogen. Doctors have been taught to be afraid of estrogen to keep them from prescribing it. There’s a fear of estrogen pounded into the heads of doctors to keep them from correctly restoring main-sex hormones in men and women. We found out in our clinic it must be because when we keep the patients’ hormones in healthy ranges, we don’t have to write prescriptions for conditions that do not exist. 85% of the reasons people go to the doctor for is a hormone deficiency issue. The big problem with mitral valve prolapse’s is that women are more symptomatic with palpitations and cardiac arrhythmias. Estrogen reduces the tendency to develop palpitations and cardiac arrhythmias. The only time estrogen causes problems is when it’s kept too low.

Upon stopping the hormone therapy, she never had another period after that, and was still under 50 years of age. Doctor’s said without it she would likely have naturally stopped having periods several years sooner”

Moxie: Menopause is an estrogen deficiency disease and can be reversed to a relative degree depending on how long a patient has been estrogen deficient. Women who are having periods are getting enough estrogen somehow to keep the body functioning. The only way for you or your mother to feel alive and healthy is to restore hormones to levels that tell your brain you’re alive and intend to stay that way. Low hormone levels tell your brain it’s time to check out and make way for the next generation, and the body responds.

“I want to avoid medications and also don’t want to prolong it the way the medication did for her.” 

Moxie: The best way for you to avoid taking medicine to treat the symptoms of estrogen deficiency is to restore estrogen to healthy levels and maintain them there with a 4th generation HRT program like the Panacea Protocol™. Any kind of HRT is better than none. You will continue to fall apart and mentally decline unless you prevent it from doing so.


Perimenopause & Postmenopause

low estrogen moxietoons

“I am confused on Perimenopause and Postmenopause.”

Moxie: Perimenopause happens at any age when estrogen gets too low, for most women, it’s in their late 30s to late 40s. It’s more severe for women who wait until their mid 30s and beyond to have children. Think of perimenopause as puberty in reverse, and the older you get, the more rapid the decline of estrogen. Your estrogen levels dictate whether you’re in a state of reproduction or postproduction with a transitional period in between called perimenopause, otherwise known as the climacteric. The climacteric is all the horrible mental and physical deteriorations that happen in our brain and body as they decay. The lower estrogen gets, the worse the mental and physical symptoms. Keep estrogen in a state of reproduction with estrogen levels maintained in the 300-700 range, none of the decline and deterioration happen in the brain and body. PMS, perimenopause, and menopause all stem from the same thing, estrogen deficiency, the name just gets changed for according to age. Perimenopause and menopause can be avoided altogether if you keep your estrogen sound.

“I understand I have been going thru this for years and it seems symptoms are getting more intense the closer i get to stopping my cycle.”

Moxie: This is because your estrogen is getting lower and lower. It will continue to decline unless you can get your estrogen levels higher or supplement estrogen.

“Which I am understanding my body is going thur a lot of hormone changes.”

Moxie: Not only changes, but the tank is draining dry. The dryer your tank gets, the worse the symptoms of anxiety, mood swings, inability to cope, debilitating periods with clotting or lasting forever or not at all, migraines, depression, and thousands of other things we’re told are idiopathic and to live with it then given drugs to shut us up.

“But, after that year (of having no period) and I am done.?”

Moxie: This is just the beginning of the end. Your brain and body now have no function with regards to reproduce so it will now go into a living decaying state until you die. Low estrogen levels tell your brain and body that it’s time to throw in the towel and will decline until the lights go out. This mental and physical declining has some extremely miserable symptoms as we lose our minds and our bodies fall apart. This doesn’t just happen to old women; it happens to any woman whose estrogen remains suboptimal, under 300.

“I was thinking that was it, and life is back to normal?!”

Moxie: Your life will never be the same. Your libido will go, your ability to handle stress will diminish as will your self confidence and self esteem, your joints will hurts and muscles will ache. You’ll lose the ability to make cognitive decisions and making emotional connections with people will be difficult. You won’t sleep, your heart will pound out of your chest, you’ll get fat, your skin will shed like a snake, your hair will fall out and fingernails shred, you’ll yell at little kids for existing, you get anxiety and become more isolated. Nothing will make you happy, not a trip, a new pair of shoes, a new house or job or divorce. No woman is happy without estrogen. Estrogen is the peace and contentment hormone that affects every function in the brain and body right down to the core of every cell. How can you expect to feel and be “normal” when the very thing that makes us feel alive or dead is missing?

“My Mom said a few things..but nothing major”

Moxie: Your mother forgot what it’s like to be alive. Most menopausal women are only shells of who they used to be. Ask your mom what she was like in her mid twenties and ask her how she’s different now. The only difference between a 25 year old and a 55 year old is the level of hormones a woman has.

“When I read everything still have hot flashes, anxiety, ect? and still need hormones?”

Moxie: Women who have hot flashes have low estrogen. Women on hormones who have hot flashes are taking too low of a dose of estrogen. Hot flashes are an indicator of low estrogen levels. Women who maintain their estrogen in the 300-700 range, never have a hot flash. Anxiety is an estrogen deficiency disease and goes away once estrogen is sound.

“I really have been trying to listen to my body and be gentle and make changes to help it.”

Moxie: You’re doing the right thing by listening to your body. The problem is, no one has any answers for you who know what’s really going on. Doctors are intentionally left in the dark about hormone restoration because many diseases, disorders, and conditions go away or get significantly better once estrogen is restored to healthy levels again.

“I do get anxiety right after my period.sad and I get angry”

Moxie: This happens because your estrogen has been too low for a couple of weeks. You should be feeling better the next week as your estrogen will peak on Day 12 of your cycle so Day 12-14 should be your best days of the month then your estrogen will go back into a decline. If estrogen is generally to low, these hormone tides will wreak havoc on your mind and body.

“I track my times and syptoms (on phone..its called period tracker on Iphone) and that helps me.

Moxie: Good to keep track on a tracker. Now pay attention to Days 12-14 of your cycle when estrogen is at its peak; your skin will be clearer and glow, your personality will shine, you’ll be in the best mood all month, your hair will be manageable, your gums won’t bleed (unless you have perio), you won’t have mood swings, you’ll be in a more problem solving mode instead of doom and gloom, you’ll have the most self confidence and no anxiety. These couple of good days women have in the month they live for, are the days when estrogen is highest. You can see for yourself how your brain and body feels when you have enough estrogen.

“I also get achey at night..those are my pains right now..but try to eat better..etc..”

Moxie: Estrogen levels dictate “fibromyalgia” symptoms. The lower estrogen gets, the more achy and painful the body gets. The most painful days will be the days when your estrogen is the lowest.


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