Can A Woman Get Too Much Estrogen?

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Do you have too much estrogen?  A follower on Facebook asked, Can A Woman Get Too Much Estrogen? I get this question from time to time because women have heard the term estrogen dominance and it can get confusing.

Yes, you can have too much estrogen but that’s not to be confused with estrogen dominance, as they are two different things. Estrogen dominance is an estrogen deficiency issue, and having too much estrogen because your doctor is mis-dosing your hormones that take your estrogen level beyond your “Hormone Sweet Spot”, which causes a series of negative side effects. Properly optimizing hormones is intelligently administered in a way that titrates the estrogen blood serum levels up over a period of time to a certain point of which we call the “Hormone Sweet Spot”. This range for most women who check their blood on Day 12-13 of their cycle is somewhere between 300-700. There is a specific technique most doctors do not know to get their patients to this point. Our research foundation, Panacea Sciences Foundation for HRT Research, Development & Education, has clinical training protocols to help physicians and midlevels properly prescribe HRT. We found that when women went outside this range, whether above it or below it, they had what we call negative indicators.   If HRT is correctly prescribed, women cannot imagine feeling any better than they do and have virtually no negative indicators, and their labs concur; this is what we call the “Hormone Sweet Spot”. There’s a clinical skill to get patients to their “Hormone Sweet Spot”.

Estrogen dominance is often misinformed administration of low dosed hormones. We find women who take a second or third generation HRT system will get an estrogen dominance affect because the hormones are not intelligently prescribed to detoxify estrogen out of the body in a timely fashion.   Estrogen is not supposed to be stored in the body. If taken correctly, proper hormone restoration is designed to receive the hormones, utilize the hormones, and detoxify the hormones in a timely fashion. If it’s not done right, women will store that estrogen in fat until the receptor response is triggered, which never happens because the hormones are dosed too low and in the wrong way so women get fatter and fatter, and suffer from all the other miserable side effects of estrogen dominance. Women can also get estrogen dominance because of their crappy high carb and sugar diet as well. Women go to doctors for hormones as if the doctor knows what they’re doing. What women do not realize is Hormone Medicine is a specialty and going to someone who has no education or clinical training will make a mess of things and make you fat. I wrote an article about this called Estrogen Dominance or Deficient? where I discuss the difference between the two.  The Panacea Protocol is the most advance HRT system in the world and doesn’t cause estrogen dominance.  Find a clinician certified in the Panacea Protocol if you want proper hormone restoration to get rid of any estrogen dominance and lose the fat you’ve been holding onto.

Perimenopause: The Beginning of the End

 

screen-shot-2016-10-29-at-10-05-33-amOver 15+ years of listening to patient after patient complain about the same issues, you get a good sense of what perimenopausal women go through on a daily basis. They are suffering in silence as no one is coming clean with what’s really going on with them. It’s not that doctors are withholding information, it’s just they too have been purposely left in the dark about the fate of women and what they go through after age thirty. I’m not sure why no one is connecting the dots to the mental and physical decline of women and estrogen levels. It’s really not rocket science. Most women know the crappy way their feeling has something to do with her hormones. Many patients tell me they always knew it was their hormones that were the problem but no one would acknowledge it or properly address it. Most women are told they have a chemical imbalance or that it’s all in their head and given prescriptions for a cocktail of psychotropic drugs and birth control pills.

If you’re over the age of 30, I don’t have to tell you how miserable you feel underneath it all, and if you’re in menopause, you know it only gets worse. Perimenopause is the beginning of the end. It is the initial transitioning phase leading into menopause. This process is called the climacteric though that word is rarely used; today women refer to perimenopause as one condition and menopause as the other but it’s really a process of declining hormones. Women who’ve suffered with PMS or PMDD will have a more miserable climacteric experience than women who did not. The reason for this is PMS, PMDD, perimenopause, and menopause is caused by the same thing, dysfunctional ovaries, which in turn create estrogen deficiency issues. In the 1957 article Sex Steroid Influence on the Aging Process by William Masters of “Masters & Johnson” [1] he states the ovaries are the Achilles heel of women. The truth is, women spend more of their lives without functioning ovaries than with them, and it’s only a matter of when and to what extent each woman will become a victim of estrogen deficiency [2]. We’ve seen this to be clinically true with all of our female patients.

The big miss doctors are not addressing is if we know women’s brains and bodies decline as estrogen does, why aren’t we addressing this issue as first line therapy at the doctors office? Why aren’t doctors taught how to properly restore main-sex hormones to healthy levels to prevent PMS, PMDD, perimenopause, menopause, and all the other mental and physical problems associated with estrogen deficiency women are told they have to live with? It was these questions I couldn’t get real answers to that made me start Panacea Sciences Foundation for HRT Research, a start up research foundation dedicated to the advancement of hormone replacement therapy medicine and education for doctors and mid-level practitioners. As it stands now, there is no place for physicians to get proper HRT training that teaches them intelligent HRT dosing and restoration. Panacea Sciences has developed a 4th generation HRT system called the Panacea Protocol using Panacea|HRT hormones to do this very thing. We developed clinical training protocols and will have two training summits next year in California starting in the early spring of 2017 that teaches clinicians intelligent HRT dosing and restoration. If you have a doctor interested in proper HRT training, email info@panaceasciences.com with your doctor’s information we can add them to our contact list when training registration begins. Make sure you put “Physician Training” in the subject line. If you need your hormones restored, ask your doctor to get trained the right way so you can get your life back.

If you don’t have someone you can go to for your hormone deficiency issues, you can take an herbal supplement to help with your symptoms until you do.  Panacea Sciences has a nutritional supplement line specifically formulated to address the symptoms of PMS, Perimenopause, and Menopause.  Take a look at the Panacea Apothecary and see of there’s something that could help you address your estrogen deficiency symptoms until your get your hormones sound.


[1] MASTERS WH. Sex steroid influence on the aging process. American journal of obstetrics and gynecology. 74(4):733-42; discussion 742-6. 1957. [PubMed]

[2] Wilson RA, Brevetti RE, Wilson TA. Specific procedures for the elimination of the menopause. Western journal of surgery, obstetrics, and gynecology. 71(1):110-21. 1980. [pubmed]

The 5 Not-So-Fun Things About Menopause

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Ann Brenoff wrote an article for the Huffington Post entitled The 5 Not-So-Fun Things About Menopause And Tips To Deal With Them about a small study conducted by Ambren, and with Marcy Letourneau, part of the Amberen NurseAid program, they put together a menopause survival guide. This so-called “survival guide” is just that, a survival guide for women who are suffering from the symptoms of menopause, not a solution. Amberen’s motto is to “Embrace The Change” offering support from nurses with expertise in menopause. What women do not know is, these women have no education, training, or clinical success in preventing or reversing menopause, just offering support for the miserable symptoms of menopause. Who really wants to embrace the nightmare of menopause?

The truth is, menopause doesn’t have to exist at all, nor does perimenopause. The five not-so-fun things Ann Brenoff discusses in this article are all symptoms of ovarian dysfunction and can be fixed. Women with PMS, PMDD, Perimenopause and Menopause all suffer from the same thing, insufficient estrogen production. Women only have these conditions when their estrogen gets too low, and there are many reasons that cause our ovaries to stop producing estrogen.

Let me take you through the five not-so-fun things about menopause from the perspective of addressing the root cause of each issue:

1. Sex can hurt–Brenoff discusses vaginal atrophy and lack of lubrication for painful sex. She is right. Women with declining estrogen, no matter how old she is, will dry up all over her body and be unable to lubricate her vagina. The vagina isn’t the only thing that dries up when estrogen declines, the oral cavity, eyes, skin, nails, hair, and many other areas our body needs lubricating. When this dehydration takes place in the body, tissue will shrink up creating atrophy throughout our body, our heart, gum tissue, lungs, and our vagina to name a few areas affected. The walls of the vagina atrophy when estrogen gets too low as the body dries up.   Without lubrication and stimulation, it hurts to have sex. In addition, an estrogen deficient woman will lose the ability to get nipple and clitoral stimulation and the connection between the two. The best way to address painful sex, a dried up vagina, and lack of lube is to get your estrogen back up into healthy reproductive ranges again. This will eliminate this problem altogether, as long as your estrogen is sound.

2. Lowered libido means less interest in having sex. You don’t have to be in menopause it have a low libido, just low in estrogen. Women who don’t have enough estrogen will not have a libido because healthy estrogen levels tells the brain of a woman what stage of life she’s in. If estrogen is low, the brain and body assume a woman is in post-production and will not have the desire to reproduce, therefore shutting down reproductive desires. Not only does an estrogen deficient woman not have a libido, she no longer is able to make emotional connections with others: children, spouses, girlfriends, and the general population, avoiding eye contact. Women without enough estrogen do not like to be touched and will send out repellent pheromones to shoo away anyone considering approaching her. When a woman’s estrogen remains low, human touch can be like touching someone with sunburn. The only thing that truly addresses the libido in women is healthy levels of estrogen. Estrogen is the sensuality and sexuality hormone for women and when it remains too low, we can’t expect them to connect or want to have sex. The best way to address this not-so-fun thing is to keep estrogen levels sound.

3. Your skin will break out so badly that you’ll think you’re back in puberty. Brenoff is right with exercise increases blood flow to all organs stating it’s the increase in oxygen that makes the skin healthier but the truth is, estrogen levels and gut dysfunction are the culprits for acne for menopausal women. Women with healthy levels of estrogen and a clean gut never get acne. What Brenoff doesn’t say is exercise is the best way to get blood flowing to the ovaries so they can produce more estrogen to address the acne. The quality of a woman’s skin is dependent on estrogen levels. When estrogen is low, skin gets dry, bumpy, pimply, and cracks. Getting physical exercise in the sun without sunscreen is the most effective way to increase estrogen production if the ovaries are still functioning. If ovaries are dysfunctional, supplementing estrogen back to healthy levels and cleaning out the gut is the only way to completely eliminate acne altogether.

4. You may forget what sleep is. Brenoff suggests that women don’t sleep because of hot flashes but the truth is, when estrogen remains too low, women will have a difficult time falling and staying asleep regardless if they have hot flashes or not. Hot flashes many keep some awake but hot flashes is also a symptom of estrogen deficiency and will go away once estrogen is sound. Estrogen levels decided whether a woman will sleep or not, and testosterone levels will determine if men will sleep or not. Addressing the main-sex hormone decline will get you to fall asleep and stay asleep for good. There is no better sleep aid.

5. Your moods may range from weepy depressed to murderously angry with little in between. Estrogen levels dictate a woman’s self esteem and self-confidence just like testosterone does in men. Only women with low estrogen have mood swings and are irritable. Women with healthy levels of estrogen are not moody or irritable and their responses are proportionate to the situation at hand. Estrogen is the mood stabilizing hormone for women and when it remains too low, you never know what you’re going to get. When estrogen is sound, women feel alive and content. When estrogen is too low, women will feel like the walking dead and be too difficult to be around.

If these things not-so-fun things about menopause are bothering you, find yourself a practitioner who has training, experience and success with high dose estrogen therapies. Going to a doctor who’s afraid of estrogen will only offer you products, drugs, and procedures to treat your estrogen deficiency symptoms. To get rid of these problems altogether, restore estrogen to reproductive levels and you will never deal with any of these symptoms again. Learn more about menopause and the causes of it so you can avoid it for good.

Beauty Lies in the Beholder of Estrogen

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“Let him kiss me with the kisses of his mouth – for your love is more delightful than wine.”[1]

Song of Solomon 1:2

She lingered for just a moment by the brook that runs through their family’s vineyard. I mustn’t risk discovery she pondered as she curled her toes into the sand warmed by the morning sun. Absence of the familiar boisterous noises flagged her memory. Ah yes, her brothers were out hunting, and wouldn’t be there to find her not tending to the young grape buds. I feel good, she mused to herself as her darkly sun bronzed legs carried her like a gazelle up the terraced hillside in search of her lover. Thoughts of her lover’s kiss danced lightly on the corners of her mind. Her body hungered for his attention and touch. “Oh that you would kiss me with the kisses of your mouth!”[2] “Oh that his left hand were under my head, and his right hand embraced me!”[3] “For your love is better than wine.”[4]

Her heart thrilled when she spotted her lover shepherding his flock for a drink down by the brook. No longer could she resist. Where have you been, my lover? “If you do not know, O fairest among women, following the flock.”[5] Hidden in this ancient text can be found the ageless notions of beauty, health, love and romance. It is a love story whose meaning will continue until the end of time.  

The desire to be beautiful is woven into the soul of every woman, and yet without estrogen there could be no feminine beauty, love, romance, passion, sexual desire, or procreation. Beauty, sex and estrogen lies at the epicenter of a woman’s ability to reap the rewards associated with beauty, good health, long life, sense of wellbeing, her capacity to establish meaningful emotional connections with others, and desire for sex.

Estrogen is the most ancient of all hormones.[6]  Even today, estrogen is critical to a woman’s body for a wide range of biologic processes. To achieve the distinction as “fairest of them all,” as king Solomon’s bride was, requires the convergence of multiple factors. Estrogen not only fashions the secondary sexual characteristics at puberty but also plays an important function at maintaining those characteristics throughout a woman’s life. How a woman looks, or how she feels has more to do with her estrogen production than any other single factor. This is why scrupulous attention to the factors responsible for optimal estrogen production is necessary for a woman to achieve her full biologic potential.

Thousands of physiological functions in the female body are directly dependent on estrogen for regulation. When estrogen goes missing there is a death signal propagated throughout her body heralding the start of a progressive downward spiral of deterioration. Long before she lays her ovaries in their final resting place she begins to experience distressing changes that rob her of health, beauty, joy, energy, sleep, memory, and sexual passion.

In the case of Solomon’s bride, she was molded in the finest crucible Mother Nature could provide. Hidden in the details of this ancient love story are clues to the factors necessary to assure optimal estrogen production. The best thing that could have befallen her, long before she became Solomon’s bride was to be relegated by her angry brothers to tend to their family’s vineyard. Their intent was to punish her, but it served a greater purpose of placing her in the best environment for fostering estrogen biosynthesis (how the ovaries produce estrogen).

In the case of vitamin D, its receptors are strategically expressed in the ovaries and play an important role in the regulation of estrogen biosynthesis.[7]  Exercise in the sun has a profound impact on physical and conformational development based on its impact on estrogen production. It turns out that “features of feminine beauty are associated with the highest estrogen levels.   Women with the highest levels of estrogen were rated as more attractive, healthier, and feminine looking than those with lower levels.”[8]  Puberty is a critical time in a woman’s development for establishing health and beauty. “These effects on appearance are likely to depend on the action of estrogen throughout puberty.”[9]

The combined insulin sensitizing effects of estradiol and vitamin D are instrumental in preventing obesity. Estradiol is a major determinant of body fat distribution, and promotes flat stomachs and sculpting of the gluteal and femoral region in ways that are pleasing to the eye. The influence of estradiol on body fat distribution appears to be related both to fat tissue specific expression of estrogen receptors and local tissue estrogen metabolism.[10]

On the other hand, estrogen is essential for the normal development, shape, tone, and function of the breast. Well-formed and perky breasts are the byproduct of sufficient estrogen, assuming adequate nutrition. Too often gravity is blamed for falling breasts when in actuality it is a symptom of declining estrogen.

When enough estrogen is present it blocks the deposition of fat in the fat cells of the stomach and trunk, while at the same time signaling the muscles to become more efficient at burning fat.[11] This important role of estrogen in determining regional body fat distribution not only results in the pleasing physical confirmation of the healthy female body, but also places her at 1/10th the risk as her male counterparts for developing cardiovascular disease.

Vitamin D, the mood boosting and feel good vitamin, is the precursor to a powerful steroid hormone that regulates the activation and deactivation of enzymes throughout the brain involved in the synthesis of neurotransmitters and nerve growth.[12]  Not only does vitamin D promote the biosynthesis of estradiol by the ovaries but also has a direct impact on neurotransmitter production, enhancing mood.

Additionally, estradiol has been recognized as an important neurotransmitter in the brain, but estradiol plays a critical role in the production of other neurotransmitters including the manufacture, release, reuptake and degradation of serotonin.[13] [14] [15]   Optimization of your estrogen production is one of the best defenses against symptoms of depression, anxiety or OCD. How a women looks and how she feels is critically dependent on her estrogen biosynthetic capacity.    

The capacity to feel spiritually grounded when life stressors seem over powering is the result of estrogen easing a woman’s stress response, and enabling her to take charge and effectively be the calm in the storm. When estrogen is at optimal levels a woman feels calm and she is much more inclined to pursue those spiritual quests that interest her.

“Upon my bed by night I sought him whom my soul loves; I sought him, but found him not; I called him, but he gave no answer. I will rise now and go about the city, in the streets and in the squares; I will seek him whom my soul loves. I sought him, but found him not. The watchman found me, as they went about the city. Have you seen him whom my soul loves? Scarcely had I passed them, when I found him whom my soul loves. I held him, and would not let him go until I had brought him into my mothers house, and into the chamber of her that conceived me.”[16]

Hardwired into the biology of every woman is the prime directive to transmit her genetic information. Whether she chooses to fulfill her prime directive is a personal choice. However, biology is destiny, and it is estrogen that transforms a woman into a fully operational reproductive female equipped with all the accouterments of sexual allure and armed not only with the capacity, but the passion to initiate a wide variety of mating rituals. The more completely estrogen can morph a woman into a work of perfection the more discriminating she can be in selecting her mate. Obviously, only the “fairest of them all” can seduce the heart of the prince, or in the case of Solomon’s bride, the King. What this means given the right environmental factors, estrogen can transform you into the best your genetic potential dictates.

In the healthy female, the desire for intercourse is primarily dictated by how much estrogen is produced. In accordance with the prime directive, the ultimate function of love, romance, and other courting rituals, as well as sex, is to propagate parental genes, and therefore reproduce the species. It is not primarily the desire to procreate, but sexual pleasure and the need to form emotional connections, facilitate bonding, and reduce sexual and interpersonal tensions, that are the prime motivators for sex. Without adequate estrogen, a woman perceives little to no need for sex. Without it, sex is no longer perceived as pleasurable, and for many, the idea of having sex becomes repulsive, leading to the avoidance of sexual intimacy all together.

The loss of sexual desire frequently leads to fractured relationships. Sex and sexual incompatibility was sited as the single most common contributing factor to divorce and is the catalyst behind 43 percent of all divorces.[17] The ability to produce estrogen is a function of how many eggs remain viable in the ovaries. As estrogen levels gradually diminish over time, 48% of women age 40 and older, never, or almost never have a spontaneous sexual thought, reflecting shifting priorities dictated by a woman’s declining egg count.

This is in stark distinction from those “sex crazed” teenagers, or those “overly sexed” college coed stereotypes of her younger years gone by. Even the female protagonist in the Song of Solomon exhibits a hungry desire for sexual intimacy with her lover. This can be ascribed to the natural outcome of possessing a healthy, fully loaded and operational reproductive system. At the most fundamental of levels humans can be defined as disposable DNA replicators imbued with the prime directive to pass on their genetic information to assure survival of the species. Both sexes are biologically invested in assuring the survival of our species and under ideal conditions exhibit comparable proclivities for sex and are equally libidinous.

If what you have just read doesn’t ring true with your own personal experience you’re not alone. Many features of modern civilization disrupt our endocrine function. Modern food consumption for example does not provide the nutritional elements necessary to support our basic physiology, nor does it have the nutritional power required to support the complexities of the female reproductive system. One reason our female protagonist developed sufficiently to be designated “the fairest of them all” was she grew up in a place once referred to as the “land flowing with milk and honey.” Not only was the soil rich and fertile, she ate an abundance of fruits and vegetables freshly harvested and organically grown from their family farm. She ingested plenty of protein, much of which came from freshly killed lamb, infused with omega 3 fatty acids. If your ovaries are to perform to their full potential, they require the best nutrition possible. Your ovaries will fail you in an environment of sugar, processed food and soda pop. Don’t expect to reap the full health and beauty benefits that estrogen can provide if your diet looks like the Standard American Diet.

In recent years estrogen’s reputation has been tarnished. Articles published in the last decade have women wary of anything that smacks of estrogen replacement. The trend by the media in recent years has been to pathologize estrogen and created fear and confusion among women and physicians alike. We have become so afraid of estrogen we have forgotten its central role in supporting every aspect of a woman’s health. When estrogen is balanced and nutritional optimization has been achieved, and there is sufficient fun in the sun, a woman’s body will function at peak efficiency. She will then reap the full benefits that estrogen was intended to supply.


[1] The Song of Solomon 1:1 Revised Standard Version

[2] The Song of Solomon 1:1 Revised Standard Version

[3] The Song of Solomon 2:6 Revised Standard Version

[4] The Song of Solomon 1:2 Revised Standard Version

[5] The Song of Solomon 1:8 Revised Standard Version

[6] Trime, Susan, “Estrogen Emerges As Most Ancient of Hormones,” Columbia University Record, Vol 26 issue 21, May 7:2001

[7] Harkness LS, Bonny AE.   Calcium and vitamin D status: key roles for bone, body weight, glucose tolerance, and estrogen biosynthesis. J Pediatr Adolesc Gynecol. 2005 Oct; 18(5): 305-311.

[8] Vance, G. (2005). Hormone Levels Predict Attractiveness of Women. Retrieved from newscientist.com/article/dn8251–hormone-levels-predict-attractiveness-of-women

[9] Vance, G. (2005). Hormone levels predict attractiveness of women. Retrieved from newscientist.com/article/dn8251–hormone-levels-predict-attractiveness-of-women

[10] Mayes JS, Watson GH. 2004   Direct effects of sex steroid hormones on adipose tissue and obesity. Obes Rev 5:197-216.

[11] Mayes JS, Watson GH. 2004   Direct effects of sex steroid hormones on adipose tissue and obesity. Obes Rev 5:197-216.

[12] Welland, D.   Does vitamin D improve brain function?   New studies show low vitamin D may impair brain function: Scientific American Mind. 2009, Nov;

[13] Fink, G., et al. Estrogen control of central neurotransmission: Effect on mood, mental state, and memory. Cellular and Molecular Neurobiology. 1996; 16(3): 325-44.

[14] Halbreich, U., et al. Role of estrogen in postmenopausal depression. Neurology. 1997; 48(5): 516. Supplement 7.

[15] Studd, J., et al. Hormones and depression in women.   Climacteric. 2004; 7(4):338-46.

[16] The Song of Solomon 3:1-4 Revise Standard Version

[17] PRLog (Press Release) 2008 Sex Is Most Common Factor In Divorce prlog.org/pressreleases/

Menstrual Migraines

screen-shot-2016-09-21-at-11-19-08-amMigraine is a common and often debilitating neurologic disorder that affects approximately 18% of women and 6% of men. Migraine prevalence is highest in women between the ages of 35 to 45 (Perimenopause), exactly during the time in her life when it is becoming more challenging for her to sustain sufficient estrogen levels throughout her menstrual cycle. Women who experience menstrual migraines typically link their migraines to a specific phase in the menstrual cycle. Menstrual migraines are typically characterized as worse and frequently less responsive to conventional treatment. They may occur as often as three to four times a week with a level of debility that may necessitate bed rest for days. The trigger for menstrual migraines is the fall in estrogen levels that occur just following ovulation, or just around the time of the period.

Headache is the most prominent feature of migraine and commonly associated with photophobia (sensitivity to light), phonophobia (sensitivity to sound), nausea and vomiting. Following a severe migraine attack the migraine sufferer frequently experiences fatigue, irritability, impaired concentration, and muscle weakness.

Migraine is now recognized as a neurovascular disorder secondary to brain dysfunction with vascular consequences that lead to head pain. Low serotonin levels in the brain are believed to mediate constriction and dilatation of the blood vessels that trigger a migraine. As the blood vessels become inflamed with every heartbeat, blood passes through these inflamed and sensitive blood vessels and causes a throbbing pain sensation, resulting in the migraine symptom complex.

Dropping estrogen levels below optimal physiological levels triggers menstrual migraines. Estradiol has been shown to affect pain processing and pain sensitivity through its regulation of serotonin. Serotonergic agonists drugs, such as Imitrex, capitalize on this principle by activating serotonin receptors to stop a migraine attack. Sometimes migraines worsen or develop for the first time in a woman’s life after menopause. The reason is the same—declining estrogen leads to declining serotonin and reduction of estrogen’s anti-inflammatory effects on the blood vessels. The best solution for menstrual and menopausal-related migraines is to treat the underlying cause—declining estrogen levels.  Restoring estrogen levels that mimic a healthy reproductive woman typically eliminates migraines in women.  As long as a woman’s estrogen is sound, she may never have another migraine as long as she lives.

 

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